IO is our job. Reasonably Smart provides carefully wrapped capabilities to read from disk, write to the datastore, and a whole bunch more. More importantly, we can do it in a secure, considered manner. This lets us run many different applications on a machine, or a cloud of machines at the same time, without having to carefully vet each codebase to make sure it's not going to do anything bad.
IronMonkey is a planned development to get IronPython and IronRuby compiling to the Tamarin Virtual Machine (the JITting ECMAScript VM that Adobe open-sourced with Mozilla a couple of years ago). When the IronMonkey project is complete Reasonably Smart will be able to support any language that compiles to the Tamarin virtual machine.